Endocrine Abstracts

Late-onset hypogonadism (LOH) remains a debatable entity in terms of diagnosis and management. However, the finding of primary hypogonadism (PHG) in ageing men, in the absence of organic cause, provides an unequivocal biochemical diagnosis. Indeed, it has been established in European Male Ageing Study (EMAS) that PHG, and not secondary hypogonadism, is strongly associated with advanced age and multi-comorbidities. That would be consistent with the underlying pathophysiology of...

Congenital hypogonadotropic hypogonadism is a rare reproductive disorder characterised by isolated deficiency in the secretion or action of gonadotropin-releasing hormone (GnRH). Diminished GnRH activity in the immediate postnatal months, a period known as minipuberty, has severe consequences on the ontogenesis of male reproductive tract. Affected infant boys may present with micropenis and cryptorchidism. Rarely, adolescents with CHH present with delayed puberty in associatio...